Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion

被引：30

作者：

Keng, D. ^{[1
]}

McAnanama, S. R. ^{[1
]}

Teraoka, I. ^{[1
]}

Arnold, S. ^{[1
]}

机构：

[1] Polytech Univ, MicroParticle PhotoPhys Lab, Brooklyn, NY 11201 USA

来源：

APPLIED PHYSICS LETTERS | 2007年 / 91卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.2778351

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Nanoparticles suspended in the vicinity of a whispering gallery mode (WGM) biosensor are detected from fluctuations in the driving light-guide transmission. These fluctuations are described by Brownian particles perturbing the resonance wavelength in reaction to being polarized by the WGM's evanescent field. Comparison between the autocorrelation of the measured fluctuations and theory provides a first order approximation for the nanoparticle size and lays the basis for future studies of interfacial dynamics. With this advance, the WGM biosensor goes beyond low-frequency measurements of adsorption and desorption and into a world which has been dominated by fluorescence correlation spectroscopy, but without labels. (C) 2007 American Institute of Physics.

引用

页数：3

共 15 条

[1] Label-free, single-molecule detection with optical microcavities [J].

Armani, Andrea M. ;

Kulkarni, Rajan P. ;

Fraser, Scott E. ;

Flagan, Richard C. ;

Vahala, Kerry J. .

SCIENCE, 2007, 317 (5839) :783-787

[2] Shift of whispering-gallery modes in microspheres by protein adsorption [J].

Arnold, S ;

Khoshsima, M ;

Teraoka, I ;

Holler, S ;

Vollmer, F .

OPTICS LETTERS, 2003, 28 (04) :272-274

[3]

ARNOLD S, FARADAY DISCUSS, V137

[4] OBSERVATION OF STRUCTURE RESONANCES IN THE FLUORESCENCE-SPECTRA FROM MICROSPHERES [J].

BENNER, RE ;

BARBER, PW ;

OWEN, JF ;

CHANG, RK .

PHYSICAL REVIEW LETTERS, 1980, 44 (07) :475-478

[5] THE SLOW MOTION OF A SPHERE THROUGH A VISCOUS FLUID TOWARDS A PLANE SURFACE [J].

BRENNER, H .

CHEMICAL ENGINEERING SCIENCE, 1961, 16 (3-4) :242-251

[6] Biochemical sensors based on polymer microrings with sharp asymmetrical resonance [J].

Chao, CY ;

Guo, LJ .

APPLIED PHYSICS LETTERS, 2003, 83 (08) :1527-1529

[7] Morphology-dependent resonances of a microsphere-optical fiber system [J].

Griffel, G ;

Arnold, S ;

Taskent, D ;

Serpenguzel, A ;

Connolly, J ;

Morris, N .

OPTICS LETTERS, 1996, 21 (10) :695-697

[8] Refractometric sensors based on microsphere resonators [J].

Hanumegowda, NM ;

Stica, CJ ;

Patel, BC ;

White, I ;

Fan, XD .

APPLIED PHYSICS LETTERS, 2005, 87 (20) :1-3

[9] Phase-matched excitation of whispering-gallery-mode resonances by a fiber taper [J].

Knight, JC ;

Cheung, G ;

Jacques, F ;

Birks, TA .

OPTICS LETTERS, 1997, 22 (15) :1129-1131

[10] Nanolayer characterization through wavelength multiplexing of a microsphere resonator [J].

Noto, M ;

Vollmer, F ;

Keng, D ;

Teraoka, I ;

Arnold, S .

OPTICS LETTERS, 2005, 30 (05) :510-512

← 1 2 →