Exosomes in Viral Disease

被引：145

作者：

Anderson, Monique R. ^{[1
,2
]}

Kashanchi, Fatah ^{[3
]}

Jacobson, Steven ^{[1
]}

机构：

[1] NINDS, NIH, Neuroimmunol Branch, Viral Immunol Sect, Bethesda, MD 20892 USA

[2] Univ Virginia, Sch Med, Dept Pathol, Mol & Cellular Basis Dis Grad Program, Charlottesville, VA 22903 USA

[3] George Mason Univ, Natl Ctr Biodef & Infect Dis, Mol Virol Lab, Manassas, VA 20110 USA

来源：

NEUROTHERAPEUTICS | 2016年 / 13卷 / 03期

关键词：

Exosomes; microvesicles; multivesicular bodies; back fusion; ESCRT; CELL-DERIVED EXOSOMES; MATURE DENDRITIC CELLS; STRUCTURES L-PARTICLES; HEPATITIS-C VIRUS; EXTRACELLULAR VESICLES; T-CELLS; SECRETE EXOSOMES; EBOLA-VIRUS; DC-SIGN; REPLICATION-COMPETENT;

D O I：

10.1007/s13311-016-0450-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Viruses have evolved many mechanisms by which to evade and subvert the immune system to ensure survival and persistence. However, for each method undertaken by the immune system for pathogen removal, there is a counteracting mechanism utilized by pathogens. The new and emerging role of microvesicles in immune intercellular communication and function is no different. Viruses across many different families have evolved to insert viral components in exosomes, a subtype of microvesicle, with many varying downstream effects. When assessed cumulatively, viral antigens in exosomes increase persistence through cloaking viral genomes, decoying the immune system, and even by increasing viral infection in uninfected cells. Exosomes therefore represent a source of viral antigen that can be used as a biomarker for disease and targeted for therapy in the control and eradication of these disorders. With the rise in the persistence of new and reemerging viruses like Ebola and Zika, exploring the role of exosomes become more important than ever.

引用

页码：535 / 546

页数：12

共 149 条

[1]

Direct exosome stimulation of peripheral human T cells detected by ELISPOT [J].