Tissue distribution of 35S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure

被引：72

作者：

Borg, D. ^{[2
]}

Bogdanska, J. ^{[3
]}

Sundstrom, M. ^{[4
]}

Nobel, S. ^{[3
]}

Hakansson, H. ^{[2
]}

Bergman, A. ^{[4
]}

DePierre, J. W. ^{[3
]}

Halldin, K. ^{[2
]}

Bergstrom, U. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Environm Toxicol, SE-75236 Uppsala, Sweden

[2] Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden

[3] Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden

[4] Stockholm Univ, Dept Mat & Environm Chem, SE-10691 Stockholm, Sweden

来源：

REPRODUCTIVE TOXICOLOGY | 2010年 / 30卷 / 04期

关键词：

Perfluorooctane sulfonate (PFOS); Perfluoroalkylated compounds (PFCs); Autoradiography; Liquid scintillation counting; Perinatal; Tissue distribution; C57Bl/6; mouse; PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; POLYFLUOROALKYL CHEMICALS; NEONATAL-MORTALITY; NATIONAL-HEALTH; US POPULATION; BLOOD; LIVER; ACID; RATS;

D O I：

10.1016/j.reprotox.2010.07.004

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to S-35-PFOS (12 5 mg/kg) we determined the distribution in dams fetuses (GD18 and GD20) and pups (postnatal day 1 PND1) employing whole-body autoradiography and liquid scintillation counting In dams levels were highest in liver and lungs After placental transfer S-35-PFOS was present on GD18 at 2-3 times higher levels in lungs liver and kidneys than in maternal blood In PND1 pups levels in lungs were significantly higher than in GD18 fetuses A heterogeneous distribution of S-35-PFOS was observed in brains of fetuses and pups with levels higher than in maternal brain This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages (C) 2010 Elsevier Inc All rights reserved

引用

页码：558 / 565

页数：8

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