Nitazoxanide: clinical studies of a broad-spectrum anti-infective agent

被引:23
作者
Aslam, Saima [1 ,2 ]
Musher, Daniel M. [1 ,2 ]
机构
[1] Michael E DeBakey VA Med Ctr, Infect Dis Sect, Houston, TX 77030 USA
[2] Baylor Coll Med, Infect Dis Sect, Houston, TX 77030 USA
关键词
clinical trials; Cryptosporidium; Giardia; nitazoxanide;
D O I
10.2217/17460913.2.6.583
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Nitazoxanide is a new compound with broad-spectrum activity against numerous intestinal protozoa, helminths and anaerobic bacteria. It is approved for the treatment of diseases caused by Giardia intestinalis and Cryptosporidium species. The drug is well tolerated, with few side effects and requires a short course of treatment. Further investigations regarding its use in patients with AIDS is needed. Nitazoxanide represents a significant advance in the treatment of intestinal parasitic infections worldwide.
引用
收藏
页码:583 / 590
页数:8
相关论文
共 35 条
[1]   Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: A report on 546 patients in Egypt [J].
Abaza, H ;
El-Zayadi, AR ;
Kabil, SM ;
Rizk, H .
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1998, 59 (02) :116-121
[2]  
Abdel-Maboud Amina I., 2000, Journal of the Egyptian Society of Parasitology, V30, P717
[3]   Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial [J].
Amadi, B ;
Mwiya, M ;
Musuku, J ;
Watuka, A ;
Sianongo, S ;
Ayoub, A ;
Kelly, P .
LANCET, 2002, 360 (9343) :1375-1380
[4]  
Broekhuysen J, 2000, INT J CLIN PHARM TH, V38, P387
[5]   Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico [J].
Cabello, RR ;
Guerrero, LR ;
Garcia, MDM ;
Cruz, AG .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1997, 91 (06) :701-703
[6]   Hymenolepis nana infection:: symptoms and response to nitazoxanide in field conditions [J].
Chero, Juan C. ;
Saito, Mayuko ;
Bustos, Javier A. ;
Blanco, Eladio M. ;
Gonzalvez, Guillermo ;
Garcia, Hector H. .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2007, 101 (02) :203-205
[7]   Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children [J].
Davila-Gutierrez, CE ;
Vasquez, C ;
Trujillo-Hernandez, B ;
Huerta, M .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 66 (03) :251-254
[8]   Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico [J].
Diaz, E ;
Mondragon, J ;
Ramirez, E ;
Bernal, R .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2003, 68 (04) :384-385
[9]   Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infections associated with acquired immunodeficiency syndrome in tropical Africa [J].
Doumbo, O ;
Rossignol, JF ;
Pichard, E ;
Traore, HA ;
Dembele, M ;
Diakite, M ;
Traore, F ;
Diallo, DA .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 56 (06) :637-639
[10]   Double-blind, randomized, placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru [J].
Favennec, L ;
Ortiz, JJ ;
Gargala, G ;
Chegne, NL ;
Ayoub, A ;
Rossignol, JF .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 17 (02) :265-270