Inhibitors of hepatitis C virus NS3•4A protease 1.: Non-charged tetrapeptide variants

被引：29

作者：

Perni, RB ^{[1
]}

Britt, SD ^{[1
]}

Court, JC ^{[1
]}

Courtney, LF ^{[1
]}

Deininger, DD ^{[1
]}

Farmer, LJ ^{[1
]}

Gates, CA ^{[1
]}

Harbeson, SL ^{[1
]}

Kim, JL ^{[1
]}

Landro, JA ^{[1
]}

Levin, RB ^{[1
]}

Luong, YP ^{[1
]}

O'Malley, ET ^{[1
]}

Pitlik, J ^{[1
]}

Rao, BG ^{[1
]}

Schairer, WC ^{[1
]}

Thomson, JA ^{[1
]}

Tung, RD ^{[1
]}

Van Drie, JH ^{[1
]}

Wei, YY ^{[1
]}

机构：

[1] Vertex Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 22期

关键词：

D O I：

10.1016/j.bmcl.2003.08.050

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P-1 and P-2 inhibitor positions is discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4059 / 4063

页数：5

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