Methyl Gallate Inhibits the Production of Interleukin-6 and Nitric Oxide via Down-Regulation of Extracellular-Signal Regulated Protein Kinase in RAW 264.7 Cells

被引：28

作者：

Chae, Hee-Sung ^{[1
]}

Kang, Ok-Hwa ^{[1
]}

Choi, Jang-Gi ^{[1
]}

Oh, You-Chang ^{[1
]}

Lee, Young-Seob ^{[1
]}

Brice, Obiang-Obounou ^{[1
]}

Chong, Myong-Soo ^{[2
]}

Lee, Ki-Nam ^{[2
]}

Shin, Dong-Won ^{[3
]}

Kwon, Dong-Yeul ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Wonkwang Oriental Med Res Inst, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Coll Oriental Med, Dept Prevent Med, Iksan 570749, Chonbuk, South Korea

[3] Sunchon Natl Univ, Dept Oriental Med Resources, Jeonnam 540742, South Korea

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2010年 / 38卷 / 05期

关键词：

Methyl Gallate; NO; ERK; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SYNTHASE; MACROPHAGES; LIPOPOLYSACCHARIDE; CYCLOOXYGENASE-2; P38; INFLAMMATION; EXPRESSION; PATHWAYS; MOUSE;

D O I：

10.1142/S0192415X10008391

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

To determine the anti-inflammatory and analgesic activities of methyl gallate (MG) isolated from Galla Rhois, MG was studied in vivo for its analgesic activities using the writhing response in mice. Anti-inflammatory activity of MG was evaluated for NO and IL-6 production in RAW 264.7 cells. MG inhibited LPS-induced NO and IL-6 production. Consistent with these observations, the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by MG. Moreover, MG suppressed the phosphorylation of ERK1/2 in LPS-induced RAW 264.7 cells in a dose-dependent manner. Taken together, the results of this study indicate that MG has anti-inflammatory effects.

引用

页码：973 / 983

页数：11

共 27 条

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Growth-inhibitory effects of Galla Rhois derived tannins on intestinal bacteria [J].