Salivary gland scintigraphy in Sjogren's syndrome and patients with sicca symptoms but without Sjogren's syndrome:: the psychological profiles and predictors for salivary gland dysfunction

被引:14
作者
Tensing, EK
Nordström, DC
Solovieva, S
Schauman, KO
Sippo-Tujunen, I
Helve, T
Natah, S
Ma, J
Li, TF
Konttinen, YT
机构
[1] Univ Helsinki, Biomedicum, Inst Biomed Anat, FIN-00029 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Dept Med Invartes Med, Helsinki, Finland
[3] Malmi Hosp, Clin Lab Dept, Helsinki, Finland
[4] Orthoped Hosp Invalid Fdn, Helsinki, Finland
关键词
D O I
10.1136/ard.62.10.964
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To characterise the psychological profiles of Sjogren's syndrome (SS) and patients with sicca symptoms but without SS; to find predictors for salivary gland function; to evaluate salivary scintigraphy as a method to differentiate between SS and patients with sicca symptoms but without SS. Patients and methods: Psychological tests (Medical Outcomes Study Short Form General Health Survey (SF-36), Jenkins Activity Survey, Toronto Alexithymia Scale, and Maastricht Questionnaire for vital exhaustion) were performed and assessment of the function of the salivary glands made in 26 patients with primary SS, 8 with secondary SS, and 9 with sicca symptoms but without SS. Data were analysed with BMDP new system version 1.0 statistical program. Results: Psychological profiles were similar in all groups. Hb, RF, ANA, and SSA differentiated between the groups. Results of salivary scintigraphy were predicted to 51% by ANA, SSA, SSB, IgG, IgA, diagnosis, vitality, and role limitations due to emotional problems. No predictors were found for the resting salivary flow. Salivary scintigraphy was pathological in 21/26 (81%) and in 8/8 (100%) patients with secondary SS, but only in 2/9 (22%) patients with sicca symptoms without SS (p = 0.002) (sensitivity 85.3%, specificity 77.8%). Conclusions: Patients with sicca symptoms but without SS have sickness behaviour similar to that of patients with SS. The results of salivary scintigraphy can be predicted by diagnosis and autoimmune findings; psychological characteristics added 20% to this predictive value. Distinction between SS and patients with sicca symptoms but without SS is difficult, but in addition to autoantibodies, salivary scintigraphy can be used for this purpose.
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页码:964 / 968
页数:5
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