Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells

被引：77

作者：

Rachakatla, Raja Shekar ^{[1
]}

Balivada, Sivasai ^{[1
]}

Seo, Gwi-Moon ^{[1
]}

Myers, Carl B. ^{[4
]}

Wang, Hongwang ^{[2
]}

Samarakoon, Thilani N. ^{[2
]}

Dani, Raj ^{[2
]}

Pyle, Marla ^{[1
]}

Kroh, Franklin O. ^{[3
]}

Walker, Brandon ^{[3
]}

Leaym, Xiaoxuan ^{[3
]}

Koper, Olga B. ^{[3
]}

Chikan, Viktor ^{[2
]}

Bossmann, Stefan H. ^{[2
]}

Tamura, Masaaki ^{[1
]}

Troyer, Deryl L. ^{[1
]}

机构：

[1] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA

[2] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA

[3] NanoScale Corp, Manhattan, KS 66502 USA

[4] Kansas State Univ, Dept Diagnost Pathobiol, Manhattan, KS 66506 USA

来源：

ACS NANO | 2010年 / 4卷 / 12期

关键词：

nanotechnology; cell-based; targeted delivery; magnetic nanoparticles; magnetic hyperthermia; melanoma; neural progenitor cells; MESENCHYMAL STEM-CELLS; NF-KAPPA-B; IRON-OXIDE NANOPARTICLES; GENE-THERAPY; CANCER CELLS; IN-VIVO; BILIVERDIN REDUCTASE; PROTEOMIC ANALYSIS; PANCREATIC-CANCER; BREAST-CANCER;

D O I：

10.1021/nn100870z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/ Iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane - porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/ shell Fe/Fe3O4 MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures.

引用

页码：7093 / 7104

页数：12

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