Binuclear ruthenium(II) phenanthroline compounds with extreme binding affinity for DNA

被引：112

作者：

Lincoln, P

Norden, B

机构：

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 18期

关键词：

D O I：

10.1039/cc9960002145

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dimeric homochiral ruthenium complexes [L(2)Ru{dppz(11-11')dppz}RuL(2)](4+) (L = 1,10-phenanthroline, 2,2'-bipyridyl; dppz = dipyrido[3,2-A:2',3'-C]phenazine) bind extremely strongly to duplex DNA with different binding geometries for the Delta Delta and Lambda Lambda enantiomers of the phenanthroline complex but with similar geometries for the bipyridyl complex enantiomers.

引用

页码：2145 / 2146

页数：2

共 8 条

[1]

CHOW CS, 1992, METHOD ENZYMOL, V212, P219

[2]

FRIEDMAN AE, 1991, NUCLEIC ACIDS RES, V19, P2595

[3] INTERACTION OF DELTA-[RU(PHEN)(2)DPPZ](2+) AND LAMBDA-[RU(PHEN)(2)DPPZ](2+) WITH DNA - A CALORIMETRIC AND EQUILIBRIUM BINDING STUDY [J].