Poly(ADP-ribose) makes a date with death

被引：133

作者：

Heeres, James T. ^{[1
,2
]}

Hergenrother, Paul J. ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Chem, Roger Adams Lab, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Biochem, Roger Adams Lab, Urbana, IL 61801 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2007年 / 11卷 / 06期

关键词：

D O I：

10.1016/j.cbpa.2007.08.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ADP-ribose) polymerase (PARP) enzymes catalyze the conversion of NAD(+) to polymers of poly(ADP-ribose) (PAR). Although its role in the DNA-damage response has long been recognized, recent work indicates that PAR itself acts at the mitochondria to directly induce cell death through stimulation of apoptosis-inducing factor (AIF) release. This review discusses PAR synthesis and degradation, and the role of PAR misregulation in various disease states. Attention is given to opportunities for therapeutic intervention with small molecules that are involved in PAR signaling, with specific focus on poly(ADP-ribose) glycohydrolase (PARG) and AIF.

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收藏

页码：644 / 653

页数：10

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