The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy

被引：59

作者：

van der Meel, Roy ^{[2
]}

Symons, Marc H. ^{[3
]}

Kudernatsch, Robert ^{[4
]}

Kok, Robbert J. ^{[2
]}

Schiffelers, Raymond M. ^{[2
]}

Storm, Gert ^{[2
]}

Gallagher, William M. ^{[5
]}

Byrne, Annette T. ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Physiol & Med Phys, Dublin 18, Ireland

[2] Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CG Utrecht, Netherlands

[3] N Shore LIJ, Feinstein Inst Med Res, Ctr Oncol & Cell Biol, Manhasset, NY 11030 USA

[4] Charite Univ Med Berlin, Inst Med Immunol, D-10117 Berlin, Germany

[5] Univ Coll Dublin, UCD Conway Inst, UCD Sch Biomol & Biomed Sci, Dublin 4, Ireland

来源：

DRUG DISCOVERY TODAY | 2011年 / 16卷 / 5-6期

基金：

爱尔兰科学基金会;

关键词：

ENDOTHELIAL GROWTH-FACTOR; SMALL-MOLECULE INHIBITOR; NUCLEOTIDE-EXCHANGE FACTORS; VASCULAR LUMEN FORMATION; COA REDUCTASE INHIBITOR; ANGIOGENESIS IN-VITRO; RHO-KINASE INHIBITOR; CELL-MIGRATION; TUMOR ANGIOGENESIS; BREAST-CANCER;

D O I：

10.1016/j.drudis.2011.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has become increasingly apparent that current antiangiogenic therapy elicits modest effects in clinical settings. In addition, it remains challenging to treat cancer metastasis through antiangiogenic regimes. Rho GTPases are essential for vascular endothelial growth factor (VEGF)-mediated angiogenesis and are involved in tumour cell invasion. This review discusses novel therapeutic strategies that interfere with Rho GTPase signalling and further explores this network as a target for anticancer therapy through interference with tumour angiogenesis and invasion. Recent findings describe the development of innovative Rho GTPase inhibitors. Positive clinical effects of Rho GTPase targeting in combination with conventional anticancer therapy is of increasing interest.

引用

页码：219 / 228

页数：10

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