Amplification of mutator cells in a population as a result of horizontal transfer

被引：22

作者：

Funchain, P ^{[1
]}

Yeung, A ^{[1
]}

Stewart, J ^{[1
]}

Clendenin, WM ^{[1
]}

Miller, JH ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BACTERIOLOGY | 2001年 / 183卷 / 12期

关键词：

D O I：

10.1128/JB.183.12.3737-3741.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutator cells that lack the mismatch repair system (MMR-) occur at rates of 10(-5) or less in laboratory populations started from wild-type cells. We show that after selection for recombinants in an interspecies mating between Salmonella enterica serovar Typhimurium and Escherichia coli, the percentage of MMR- cells rises to several percent of the recombinant population, and after a second successive mating and selection, greater than 95% of the recombinants are MMR-. Coupling a single cross and selection,vith either mutagenesis or selection for spontaneous mutants also results in a dramatic increase in MMR- cells. We discuss how horizontal transfer can result in mutator strains during adaptive evolution.

引用

页码：3737 / 3741

页数：5

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