Absence of association of α1-antichymotrypsin polymorphisms with Alzheimer's disease:: A report on autopsy-confirmed cases

被引：18

作者：

Itabashi, S

Arai, H ^{[1
]}

Matsui, T

Matsushita, S

Muramatsu, T

Higuchi, S

Trojanowski, JQ

Sasaki, H

机构：

[1] Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 98077, Japan

[2] Kurihama Natl Hosp, Natl Inst Alcoholism, Yokosuka, Kanagawa 239, Japan

[3] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

EXPERIMENTAL NEUROLOGY | 1998年 / 151卷 / 02期

关键词：

Alzheimer's disease; alpha(1)-antichymotrypsin; apolipoprotein E; autopsy-confirmed; polymorphism;

D O I：

10.1006/exnr.1998.6802

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha 1-Antichymotrypsin (ACT) polymorphisms were examined in 79 cases with autopsy-confirmed Alzheimer's disease (AD) as well as in 28 cases with autopsy-confirmed nonneurological diseases to test the hypothesis that ACT polymorphisms confer a risk to an individual to develop AD. Neither ACT genotype frequency nor ACT allele frequency in the AD group was significantly different from the control group. The ACT polymorphic pattern was essentially the same among apolipoprotein E (apoE) epsilon 4 carriers and noncarriers. The age at onset of AD was not significantly affected by the inherited dose of ACT/A allele. Taking together, our observations do not confirm the effect of the ACT/A allele as a risk. factor for developing AD in addition to the ApoE epsilon 4 allele. (C) 1998 Academic Press.

引用

页码：237 / 240

页数：4

共 26 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].