Tin(IV) compounds derivatives of reaction between Organotin(IV), SNCL4 and rutin trihydrate:: Characterization and hypolipidemic effects.

被引：2

作者：

de Mello, VJ

Maia, JRD

de Oliveira, TT

Nagem, TJ

Ardisson, JD

Patrício, PSD

de Lima, GM

机构：

[1] Univ Fed Vicosa, Dept Quim, BR-36571000 Vicosa, MG, Brazil

[2] Univ Fed Vicosa, Dept Bioquim & Biol Mol, BR-36571000 Vicosa, MG, Brazil

[3] Univ Fed Ouro Preto, Dept Quim, Ouro Preto, Brazil

[4] Univ Fed Minas Gerais, Dept Quim, ICEx, Belo Horizonte, MG, Brazil

来源：

MAIN GROUP METAL CHEMISTRY | 2004年 / 27卷 / 06期

关键词：

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

Equimolar reactions involving SnClPh3, SnCl2Ph2, SnCl3Ph and SnCl4 and rutin trihydrate (Quercetin-3-rutinoside) produced organotin(IV) polymers, which have been characterized by infrared spectroscopy, H-1, C-13 and Sn-119 NMR, Mossbauer spectroscopy, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and microanalysis. The NMR (H-1, C-13) and Sn-119 Mossbauer spectroscopy have revealed dephenylation of the starting organotin(IV) materials. The overall data have revealed a six-coordination for the Sn(IV) centre in solution as well as in solid state. DSC and GPC techniques have confirmed the formation of macromolecules for those adducts with an average molar mass higher than 7.0x10(3) g/mol. The hypolipidemic effect of total cholesterol reduction in male New Zealand rabbits was comparable to calcic atorvastatin, a commercial drug for treatment of hyperlipidemic patients.

引用

页码：309 / 321

页数：13

共 36 条

[1]

Archer R.D., 2001, SPEC TOP INOR CHEM, P179

[2]

SN-119 MOSSBAUER AND X-RAY PHOTOELECTRON STUDIES OF NOVEL TIN OXIDE PILLARED LAPONITE FORMED UNDER AMBIENT CONDITIONS FROM ARYLTIN PRECURSORS - RAPID INTERCALATION REACTIONS USING MICROWAVE-HEATING [J].