Antibody protection: passive immunization dof neonates against oral AIDS virus challenge

被引：59

作者：

Ruprecht, RM

Ferrantelli, F

Kitabwalla, M

Xu, WD

McClure, HM

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

VACCINE | 2003年 / 21卷 / 24期

关键词：

neutralizing monoclonal antibodies; passive immunization and correlates of immune protection; HIV transmission through breastfeeding;

D O I：

10.1016/S0264-410X(03)00335-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have established models for intrapartum and milk-borne HIV transmission by orally challenging neonatal macaques with chimeric simian-human immunodeficiency viruses (SHIVs). This allowed us to test safety and efficacy of passive immunization with human neutralizing monoclonal antibodies (nmAbs), which had been isolated from HIV clade B-infected individuals and which target conserved, functionally important epitopes. The nmAbs studied were F105 or IgG1b12, b12 for short (directed against the CD4 binding site), 2G12 (anti-gp120), 2F5 and 4E10 (both anti-gp41). Out of 16 newborn macaques challenged orally with different SHIV strains, 11 were completely protected by triple or quadruple nmAb combinations, even by post-exposure prophylaxis. In vitro, the combination of b12, 2G12, 2175 and 4E10 potently neutralized primary HIV isolates of clades A, B, C, and D. Our data suggest that passive immunization with currently available anti-HIV clade B nmAbs could play a role in preventing transmission of non-clade B isolates through breastfeeding. We furthermore conclude that the epitopes recognized by the nmAbs in our successful passive immunization studies are important determinants for protection and provide targets for developing neutralizing antibody-response-based, active AIDS vaccines. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3370 / 3373

页数：4

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