Segment coupling to a highly hindered N-terminal, alamethicin-related α-aminoisobutyric acid (Aib) residue

被引：5

作者：

Carpino, Louis A. ^{[1
]}

Abdel-Maksoud, Adel Ali

Mansour, E. M. E.

Zewail, Mohamed A.

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[2] Genet Engn Inst, Prot Res Dept, Alexandria 21934, Egypt

[3] Univ Alexandria, Fac Sci, Dept Chem, Alexandria 21321, Egypt

[4] Natl Res Ctr, Peptide Chem Dept, Cairo 12622, Egypt

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 41期

关键词：

D O I：

10.1016/j.tetlet.2007.07.215

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A model [6+5] segment coupling process involving a C-terminal valine hexapeptide acid and a resin-attached pentapeptide amide, which N-terminated in a hindered Aib unit, was examined using a variety of HOAt-derived coupling reagents. Best results were observed with N-HAPyU in DCM solvent in which loss of configuration amounted to 5.8%. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7404 / 7407

页数：4

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