Presence of dioxins in human follicular fluid: Their possible stage-specific action on the development of preimplantation mouse embryos

被引：44

作者：

Tsutsumi, O ^{[1
]}

Uechi, H

Sone, H

Yonemoto, J

Takai, Y

Momoeda, M

Tohyama, C

Hashimoto, S

Morita, M

Taketani, Y

机构：

[1] Univ Tokyo, Fac Med, Dept Obstet & Gynecol, Bunkyo Ku, Tokyo 1138655, Japan

[2] Natl Inst Environm Studies, Environm Chem Div, Tsukuba, Ibaraki 3050053, Japan

[3] Natl Inst Environm Studies, Div Reg Environm, Tsukuba, Ibaraki 3050053, Japan

[4] Natl Inst Environm Studies, Environm Hlth Div, Tsukuba, Ibaraki 3050053, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 250卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1006/bbrc.1998.9340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Examination of human follicular fluid revealed the presence of polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs) at concentrations of approximately 1 pg/ml (0.01 pg TEQ/ml). To study their possible action, two-cell mouse embryos were cultured in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at concentrations between 0.5 and 100 pM and evaluated at 24-h intervals for their development to the eight-cell and blastocyst stages. The percentage of eight-cell embryos exposed to TCDD at 1, 2, and 5 pM concentrations was significantly lower than that of controls. However, blastocyst formation of the surviving eight-cell embryos was accelerated, with the number of cells in the blastocysts increased in a dose-dependent manner. Findings suggest that PCDDs and PCDFs may be present in human reproductive fluid and may exert some stage-specific effects on early embryonic development. (C) 1998 Academic Press.

引用

页码：498 / 501

页数：4

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