Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor β chain and P53 double-knockout mice

被引：7

作者：

Kado, S ^{[1
]}

Uchida, K ^{[1
]}

Funabashi, H ^{[1
]}

Iwata, S ^{[1
]}

Nagata, Y ^{[1
]}

Ando, M ^{[1
]}

Onoue, M ^{[1
]}

Matsuoka, Y ^{[1
]}

Ohwaki, M ^{[1
]}

Morotomi, M ^{[1
]}

机构：

[1] Yakult Cent Inst Microbiol Res, Kunitachi, Tokyo 1868650, Japan

来源：

CANCER RESEARCH | 2001年 / 61卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This study was conducted to confirm the hypothesis that intestinal microflora are required for the development of adenocarcinoma in the colon of the TCR beta and p53 double-knockout (TCR beta (-/-) p53(-/-)) mouse. Germ-free TCR beta (-/-) p53(-/-) mice were produced. At 7 weeks of age, the animals were divided into two groups (n = 10/group), and one of these groups was conventionalized. Animals of both groups were subjected to histopathological examination for adenocarcinoma of the colon at 4 months of age. There was no development of adenocarcinoma of the colon among the germ-free mice, whereas in the conventionalized group, adenocarcinomas of the ileocecum and cecum were detected in 70% of animals. These results indicate the usefulness of the TCR beta (-/-) p53(-/-) mouse as a colon cancer animal model that develops spontaneous adenocarcinoma of the colon early in life, and suggest that intestinal microflora play a major role in the development of adenocarcinoma of the colon in this animal model.

引用

页码：2395 / 2398

页数：4

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