Crosstalk and considerations in endocrine disrupter research

被引：7

作者：

Lackey, BR ^{[1
]}

Gray, SL ^{[1
]}

Henricks, DM ^{[1
]}

机构：

[1] Clemson Univ, AVS Dept, Endocrine Physiol Lab, Clemson, SC 29634 USA

来源：

MEDICAL HYPOTHESES | 2001年 / 56卷 / 06期

关键词：

D O I：

10.1054/mehy.2000.1249

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The presence of endocrine disrupting chemicals in the environment has prompted action on several fronts to assess the potential health risks of these compounds. To fully understand the mechanisms behind the observed endocrine disruption, crosstalk and other factors should be considered. In this article we will discuss how crosstalk modulates estrogen action in several common assays and how this and other considerations appear to have been overlooked. In addition, a paradigm shift from theoretical linear response pathways to interaction maps should aid in the understanding and analysis of endocrine disruption. (C) 2001 Harcourt Publishers Ltd.

引用

页码：644 / 647

页数：4

共 24 条

[1] Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta [J].

Cha, SH ;

Sekine, T ;

Kusuhara, H ;

Yu, E ;

Kim, JY ;

Kim, DK ;

Sugiyama, Y ;

Kanai, Y ;

Endou, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (06) :4507-4512

[2] Physicological coupling of growth factor and steroid receptor signaling pathways: Estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor [J].

Curtis, SW ;

Washburn, T ;

Sewall, C ;

DiAugustine, R ;

Lindzey, J ;

Couse, JF ;

Korach, KS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) :12626-12630

[3]

Duda RB, 1999, J SURG ONCOL, V72, P230, DOI 10.1002/(SICI)1096-9098(199912)72:4<230::AID-JSO9>3.0.CO

[4]

2-2

[5]

EDSTAC, 1998, Endocrine Disruptor Screening and Testing Advisory Committee, Final Report

[6] RECOMBINANT INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 INHIBITS IGF-I, SERUM, AND ESTROGEN-DEPENDENT GROWTH OF MCF-7 HUMAN BREAST-CANCER CELLS [J].

FIGUEROA, JA ;

SHARMA, J ;

JACKSON, JG ;

MCDERMOTT, MJ ;

HILSENBECK, SG ;

YEE, D .

JOURNAL OF CELLULAR PHYSIOLOGY, 1993, 157 (02) :229-236

[7] Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor [J].

Gee, AC ;

Carlson, KE ;

Martini, PGV ;

Katzenellenbogen, BS ;

Katzenellenbogen, JA .

MOLECULAR ENDOCRINOLOGY, 1999, 13 (11) :1912-1923

[8]

Gray K, 1996, MOL CARCINOGEN, V17, P163, DOI 10.1002/(SICI)1098-2744(199611)17:3<163::AID-MC9>3.0.CO

[9]

2-G

[10] Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells [J].

Guvakova, MA ;

Surmacz, E .

EXPERIMENTAL CELL RESEARCH, 1997, 231 (01) :149-162

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