Feline immunodeficiency virus cell entry

被引：29

作者：

Frey, SCS

Hoover, EA

Mullins, JI

机构：

[1] Univ Washington, Hlth Sci Ctr, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

[3] Colorado State Univ, Dept Pathol, Ft Collins, CO 80523 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 11期

关键词：

D O I：

10.1128/JVI.75.11.5433-5440.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.

引用

收藏

页码：5433 / 5440

页数：8

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