Investigating C-elegans development through mosaic analysis

被引：37

作者：

Yochem, J ^{[1
]}

Herman, RK ^{[1
]}

机构：

[1] Univ Minnesota, Dept Genet Biol & Dev, Minneapolis, MN 55455 USA

来源：

DEVELOPMENT | 2003年 / 130卷 / 20期

关键词：

D O I：

10.1242/dev.00701

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The analysis of genetically mosaic worms, in which some cells carry a wild-type gene and others are homozygous mutant, can reveal where in the animal a gene acts to prevent the appearance of a mutant phenotype. In this primer article, we describe how Caenorhabditis elegans genetic mosaics are generated, identified and analyzed, and we discuss examples in which the analysis of mosaic worms has provided important information about the development of this organism.

引用

页码：4761 / 4768

页数：8

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