Implantable bioelectronic interfaces for lost nerve functions

被引:94
作者
Heiduschka, P [1 ]
Thanos, S [1 ]
机构
[1] Univ Eye Hosp Munster, D-48149 Munster, Germany
关键词
D O I
10.1016/S0301-0082(98)00013-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuronal cells are unique within the organism. In addition to forming long-distance connections with other nerve cells and non-neuronal targets, they lose the ability to regenerate their neurites and to divide during maturation. Consequently, external violations like trauma or disease frequently lead to their disappearance and replacement by non-neuronal, and thus not properly functioning cells. The advent of microtechnology and construction of artificial implants prompted to create particular devices for specialised regions of the nervous system, in order to compensate for the loss of function. The scope of the present work is to review the current devices in connection with their applicability and functional perspectives. (1) Successful implants like the cochlea implant and peripherally implantable stimulators are discussed. (2) Less developed and not yet applicable devices like retinal or cortical implants are introduced, with particular emphasis given to the reasons for their failure to replace very complex functions like vision. (3) Material research is presented both from the technological aspect and from their biocompatibility as prerequisite of any implantation. (4) Finally: basic studies are presented, which deal with methods of shaping the implants, procedures of testing biocompatibility and modifications of improving the interfaces between a technical device and the biological environment. Thr review ends by pointing to future perspectives in neuroimplantation and restoration of interrupted neuronal pathways. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:433 / 461
页数:29
相关论文
共 284 条
[1]   SELECTIVE ACTIVATION OF PERIPHERAL-NERVE FIBER GROUPS OF DIFFERENT DIAMETER BY TRIANGULAR SHAPED STIMULUS PULSES [J].
ACCORNERO, N ;
BINI, G ;
LENZI, GL ;
MANFREDI, M .
JOURNAL OF PHYSIOLOGY-LONDON, 1977, 273 (03) :539-560
[2]  
AEBISCHER P, 1988, TISSUE ENG, P257
[3]   CONSIDERATIONS FOR SAFETY WITH CHRONICALLY IMPLANTED NERVE ELECTRODES [J].
AGNEW, WF ;
MCCREERY, DB .
EPILEPSIA, 1990, 31 :S27-S32
[4]  
AGNEW WF, 1988, DEV SAFE TECHNIQUES
[5]   A MICROMACHINED SILICON SIEVE ELECTRODE FOR NERVE REGENERATION APPLICATIONS [J].
AKIN, T ;
NAJAFI, K ;
SMOKE, RH ;
BRADLEY, RM .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1994, 41 (04) :305-313
[6]  
AKIN T, 1991, 1991 INT C SOL STAT, P128
[7]  
Albrektsson T, 1986, Int J Oral Maxillofac Implants, V1, P11
[8]   A 2-PART MODEL FOR DETERMINING THE ELECTROMAGNETIC AND PHYSIOLOGICAL BEHAVIOR OF CUFF ELECTRODE NERVE STIMULATORS [J].
ALTMAN, KW ;
PLONSEY, R .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1986, 33 (03) :285-293
[9]  
Amadori M, 1996, Acta Otorhinolaryngol Ital, V16, P324
[10]   SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS WITH POLY(ETHYLENE OXIDE), ALBUMIN, AND HEPARIN FOR REDUCED THROMBOGENICITY [J].
AMIJI, M ;
PARK, K .
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1993, 4 (03) :217-234