Synthesis of tertiary α-hydroxy acids by silylene transfer to α-keto esters

被引：29

作者：

Howard, Brett E. ^{[1
]}

Woerpel, K. A. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 22期

关键词：

D O I：

10.1021/ol702148x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Keto esters can be converted into alpha-hydroxy acids in a single flask involving metal-catalyzed silylene transfer, 6 pi-electrocyclization, Ireland-Claisen rearrangement, and hydrolysis. This reaction sequence is stereoselective and tolerates alkyl- and aryl-substituted a-keto ester substrates as well as an alpha-imino ester.

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页码：4651 / 4653

页数：3

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