Mouse models of telencephalic development

被引：23

作者：

Zaki, PA ^{[1
]}

Quinn, JC ^{[1
]}

Price, DJ ^{[1
]}

机构：

[1] Univ Edinburgh, Genes & Dev Grp, Edinburgh EH8 9XD, Midlothian, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 04期

基金：

英国惠康基金; 美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-437X(03)00084-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As the telencephalon first emerges from anterior neuroectoderm, signalling molecules and transcription factors combine to specify the identity and fate of cells in each of its regions. Studies of both naturally occurring and transgenic mutant mice have identified many genes that contribute to this process. The development of telencephalon and its regions is specified by signalling molecules produced at sites both surrounding and within the telencephalon. Different parts of the telencephalon express different combinations of transcription factors that control processes including proliferation, cell fate determination and migration in order to create the unique phenotype of each region.

引用

页码：423 / 437

页数：15

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