Mouse embryonic chimeras: tools for studying mammalian development

被引：146

作者：

Tam, PPL ^{[1
]}

Rossant, J

机构：

[1] Univ Sydney, Embryol Unit, Childrens Med Res Inst, Westmead, NSW 2145, Australia

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

来源：

DEVELOPMENT | 2003年 / 130卷 / 25期

关键词：

D O I：

10.1242/dev.00893

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Embryonic chimeras of the mouse are well-established tools for studying cell lineage and cell potential. They are also a key part of the analysis of complex phenotypes of mutant mice. By combining embryonic stem cell technology, molecularly tagged mutations and sensitive cell lineage markers, chimeras can provide invaluable insights into the tissue-specific requirement and the mode of action of many mouse genes.

引用

页码：6155 / 6163

页数：9

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