Update in pulmonary arterial hypertension 2007

被引:32
作者
Humbert, Marc [1 ]
机构
[1] Univ Paris 11, Ctr Natl Reference Hypertens Arterielle Pulm, Serv Pneumol & Reanimat Resp, Hop Antoine Beclere,AP HP, F-92140 Clamart, France
关键词
D O I
10.1164/rccm.200801-029UP
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
This article summarizes recent advances in the field of pulmonary arterial hypertension (PAH), a severe condition characterized by a progressive remodeling of small pulmonary arteries leading to elevated pulmonary vascular resistance and right ventricular failure (1, 2). Epidemiology, genetics, pathophysiology, and treatment will be the main focus of this update.
引用
收藏
页码:574 / 579
页数:6
相关论文
共 68 条
[1]   Characterization of the BMPR2 5′-untranslated region and a novel mutation in pulmonary hypertension [J].
Aldred, Micheala A. ;
Machado, Rajiv D. ;
James, Victoria ;
Morrell, Nicholas W. ;
Trembath, Richard C. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 176 (08) :819-824
[2]   Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension [J].
Anthi, Anastasia ;
Machado, Roberto F. ;
Jison, Maria L. ;
Taveira-DaSilva, Angelo M. ;
Rubin, Lewis J. ;
Hunter, Lori ;
Hunter, Christian J. ;
Coles, Wynona ;
Nichols, James ;
Avila, Nilo A. ;
Sachdev, Vandana ;
Chen, Clara C. ;
Gladwin, Mark T. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (12) :1272-1279
[3]   Congestive heart failure is a rare event in patients receiving imatinib therapy [J].
Atallah, Ehab ;
Durand, Jean-Bernard ;
Kantarjian, Hagop ;
Cortes, Jorge .
BLOOD, 2007, 110 (04) :1233-1237
[4]   Medical therapy for pulmonary arterial hypertension - Updated ACCP evidence-based clinical practice guidelines [J].
Badesch, David B. ;
Abman, Steven H. ;
Simonneau, Gerald ;
Rubin, Lewis J. ;
McLaughlin, Vallerie V. .
CHEST, 2007, 131 (06) :1917-1928
[5]   Medical therapy for pulmonary arterial hypertension - ACCP evidence-based clinical practice guidelines [J].
Badesch, DB ;
Abman, SH ;
Ahearn, GS ;
Barst, RJ ;
McCrory, DC ;
Simonneau, G ;
McLaughlin, VV .
CHEST, 2004, 126 (01) :35S-62S
[6]  
Baughman RP, 2006, SARCOIDOSIS VASC DIF, V23, P108
[7]   The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted [J].
Bonnet, Sebastien ;
Rochefort, Gael ;
Sutendra, Gopinath ;
Archer, Stephen L. ;
Haromy, Alois ;
Webster, Linda ;
Hashimoto, Kyoko ;
Bonnet, Sandra N. ;
Michelakis, Evangelos D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (27) :11418-11423
[8]   Global alliance against chronic respiratory diseases [J].
Bousquet, J. ;
Dahl, R. ;
Khaltaev, N. .
ALLERGY, 2007, 62 (03) :216-223
[9]   Severe pulmonary hypertension and chronic obstructive pulmonary disease [J].
Chaouat, A ;
Bugnet, AS ;
Kadaoui, N ;
Schott, R ;
Enache, I ;
Ducoloné, A ;
Ehrhart, M ;
Kessler, R ;
Weitzenblum, E .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 172 (02) :189-194
[10]   Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib [J].
Chu, Tammy F. ;
Rupnick, Maria A. ;
Kerkela, Risto ;
Dallabrida, Susan M. ;
Zurakowski, David ;
Nguyen, Lisa ;
Woulfe, Kathleen ;
Pravda, Elke ;
Cassiola, Flavia ;
Desai, Jayesh ;
George, Suzanne ;
Morgan, Jeffrey A. ;
Harris, David M. ;
Ismail, Nesreen S. ;
Chen, Jey-Hsin ;
Schoen, Frederick J. ;
Van den Abbeele, Annick D. ;
Demetri, George D. ;
Force, Thomas ;
Chen, Ming Hui .
LANCET, 2007, 370 (9604) :2011-2019