Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood

被引:104
作者
Kuntsi, J [1 ]
Rijsdijk, F [1 ]
Ronald, A [1 ]
Asherson, P [1 ]
Plomin, R [1 ]
机构
[1] Kings Coll London, MRC Social, Genet & Dev Psychiat Ctr, Inst Psychiat, London SE5 8AF, England
基金
英国医学研究理事会;
关键词
attention deficit hyperactivity disorder (ADHD); twin study; genetics; longitudinal; early childhood; middle childhood;
D O I
10.1016/j.biopsych.2004.12.032
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The high heritability of the core symptoms of attention-deficit/hyperactivity disorder (ADHD) has been repeatedly demonstrated, but few studies to date have investigated the extent to which the same genetic influences operate across development or new genes emerge at different developmental periods. Methods: We report data from a large, population-based study of approximately 4, 000 twin pairs, who have been followed up from early to middle childhood. Results: Parents' ratings of ADHD symptoms showed moderate stability across the ages, which was mainly due to shared genetic influences. There was also evidence of additional genetic influences, which were not shared with those acting earlier on, emerging at later age periods. The contribution of environmental influences to the stability of the ADHD symptoms over time was small. Parents' ratings on the Conners' DSM-IV ADHD subscale at the last assessment point, at an average age of 8 years, did not show the rater contrast effects that were observed in the parents' ratings at earlier ages with briefer measures. Similar estimates of genetic and environmental influences were obtained for girls and boys. Conclusions: We discuss the implications of the findings for molecular genetic studies on ADHD symptomatology.
引用
收藏
页码:647 / 654
页数:8
相关论文
共 36 条
  • [1] [Anonymous], 1999, MOL CELL ENDOCRINOL
  • [2] Attention-deficit hyperactivity disorder in the post-genomic era
    Asherson, P
    [J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2004, 13 (Suppl 1) : 50 - 70
  • [3] Predictors of persistence and remission of ADHD into adolescence: Results from a four-year prospective follow-up study
    Biederman, J
    Faraone, S
    Milberger, S
    Curtis, S
    Chen, L
    Marrs, A
    Ouellete, C
    Moore, P
    Spencer, T
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1996, 35 (03) : 343 - 351
  • [4] Biederman J, 2002, J Atten Disord, V6 Suppl 1, pS7
  • [5] The revised Conners' Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity
    Conners, CK
    Sitarenios, G
    Parker, JDA
    Epstein, JN
    [J]. JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 1998, 26 (04) : 257 - 268
  • [6] CORNIS KM, IN PRESS MOL PSYCHIA
  • [7] A MODEL OF STABILITY AND CHANGE IN MINOR PSYCHIATRIC-SYMPTOMS - RESULTS FROM 3 LONGITUDINAL-STUDIES
    DUNCANJONES, P
    FERGUSSON, DM
    ORMEL, J
    HORWOOD, LJ
    [J]. PSYCHOLOGICAL MEDICINE, 1990, : 1 - &
  • [8] Faraone Stephen, 2002, J Atten Disord, V6, P5, DOI 10.1177/108705470200600102
  • [9] DNA from buccal swabs recruited by mail: Evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping
    Freeman, B
    Smith, N
    Curtis, C
    Huckett, L
    Mill, J
    Craig, IW
    [J]. BEHAVIOR GENETICS, 2003, 33 (01) : 67 - 72
  • [10] Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample
    Gjone, H
    Stevenson, J
    Sundet, JM
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1996, 35 (05) : 588 - 596