Your bleeding heart: lessons from low tissue factor expression in mice

被引：5

作者：

McVey, JH ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Fac Med, London W12 0NN, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0165-6147(03)00121-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tissue factor (TF) is the cellular receptor and cofactor for blood coagulation factor VII (FVII). Exposure of flowing blood to cells that express TF leads to the initiation of blood coagulation. A recent study of mice expressing low levels of TF has demonstrated the importance of TF and FVII in maintaining adequate haemostasis within the heart. In addition, the study indicates that the heart is subject to a succession of minor bleeds most probably as a result of repetitive minor mechanical injury to the blood vessels.

引用

页码：269 / 272

页数：4

共 26 条

[1]

BORK P, 1995, TRENDS BIOCH SCI, V20

[2] TISSUE FACTOR PROMOTES MELANOMA METASTASIS BY A PATHWAY INDEPENDENT OF BLOOD-COAGULATION [J].

BROMBERG, ME ;

KONIGSBERG, WH ;

MADISON, JF ;

PAWASHE, A ;

GAREN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (18) :8205-8209

[3] Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation [J].

Bugge, TH ;

Xiao, Q ;

Kombrinck, KW ;

Flick, MJ ;

Holmback, K ;

Danton, HJS ;

Colbert, MC ;

Witte, DP ;

Fujikawa, K ;

Davie, EW ;

Degen, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6258-6263

[4] Normal thrombin generation [J].

Butenas, S ;

van't Veer, C ;

Mann, KG .

BLOOD, 1999, 94 (07) :2169-2178

[5] Mechanism of factor VIIa-dependent coagulation in hemophilia blood [J].

Butenas, S ;

Brummel, KE ;

Branda, RF ;

Paradis, SG ;

Mann, KG .

BLOOD, 2002, 99 (03) :923-930

[6] Role of tissue factor in embryonic blood vessel development [J].

Carmeliet, P ;

Mackman, N ;

Moons, L ;

Luther, T ;

Gressens, P ;

VanVlaenderen, I ;

Demunck, H ;

Kasper, M ;

Breier, G ;

Evrard, P ;

Muller, M ;

Risau, W ;

Edgington, T ;

Collen, D .

NATURE, 1996, 383 (6595) :73-75

[7] Thrombin signalling and protease-activated receptors [J].

Coughlin, SR .

NATURE, 2000, 407 (6801) :258-264

[8] Fatal haemorrhage and incomplete block to embryogenesis in mice locking coagulation factor V [J].

Cui, JS ;

OShea, KS ;

Purkayastha, A ;

Saunders, TL ;

Ginsburg, D .

NATURE, 1996, 384 (6604) :66-68

[9] Blood coagulation factor x deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice [J].

Dewerchin, M ;

Liang, Z ;

Moons, L ;

Carmeliet, P ;

Castellino, FJ ;

Collen, D ;

Rosen, ED .

THROMBOSIS AND HAEMOSTASIS, 2000, 83 (02) :185-190

[10] The TF:VIIa complex:: Clinical significance, structure-function relationships and its role in signaling and metastasis [J].

Konigsberg, W ;

Kirchhofer, D ;

Riederer, MA ;

Nemerson, Y .

THROMBOSIS AND HAEMOSTASIS, 2001, 86 (03) :757-771

← 1 2 3 →