Biosynthesis of the Off-Flavor 2-Methylisoborneol by the Myxobacterium Nannocystis exedens

被引：110

作者：

Dickschat, Jeroen S.

Nawrath, Thorben

Thiel, Verena

Kunze, Brigitte

Mueller, Rolf

Schulz, Stefan

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Organ Chem, D-38106 Braunschweig, Germany

[2] Helmholtz Zentrum Infektionsforsch, D-38124 Braunschweig, Germany

[3] Univ Saarland, Inst Pharmazeut Biotechnol, D-66123 Saarbrucken, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期

关键词：

biosynthesis; mass spectrometry; myxobacteria; terpenes; volatiles;

D O I：

10.1002/anie.200702496

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A bouquet of bacteria: Methylisoborneol (1) is a widely occurring volatile from bacteria and an undesirable flavor (off-flavor) in the food industry. The analysis of isotopomers obtained by feeding isotopically labeled precursors to myxobacteria revealed the biosynthetic pathway to 1. Geranylpyrophosphate (CPP) is alkylated by S-adenosylmethionine (SAM) and the product is cyclized to 1. The methylation of GPP is unprecedented in nature. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8287 / 8290

页数：4

共 29 条

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[Anonymous], [No title captured]

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