Sex chromosome coemplement regulates habit formation

被引：116

作者：

Quinn, Jennifer J.

Hitchcott, Paul K.

Umeda, Elizabeth A.

Arnold, Arthur P.

Taylor, Jane R.

机构：

[1] Yale Univ, Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Facil, Div Mol Psychiat, New Haven, CT 06508 USA

[2] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 11期

关键词：

D O I：

10.1038/nn1994

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sex differences in brain function and behavior are regularly attributed to gonadal hormones. Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not mediated by gonadal hormones. We used mice in which sex chromosome complement (XX versus XY) and gonadal sex ( ovaries versus testes) were independent, and found that XX mice showed faster food-reinforced instrumental habit formation than XY mice, regardless of gonadal phenotype.

引用

页码：1398 / 1400

页数：3

共 14 条

[1] GONADAL-STEROID INDUCTION OF STRUCTURAL SEX-DIFFERENCES IN THE CENTRAL NERVOUS-SYSTEM [J].

ARNOLD, AP ;

GORSKI, RA .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :413-442

[2] The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse [J].

Burgoyne, PS ;

Thornhill, AR ;

Boudrean, SK ;

Darling, SM ;

Bishop, CE ;

Evans, EP .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1995, 350 (1333) :253-260

[3] Why sex matters for neuroscience [J].

Cahill, Larry .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (06) :477-484

[4] Sex chromosome genes directly affect brain sexual differentiation [J].

Carruth, LL ;

Reisert, I ;

Arnold, AP .

NATURE NEUROSCIENCE, 2002, 5 (10) :933-934

[5]

De Vries GJ, 2002, J NEUROSCI, V22, P9005

[6] ACTIONS AND HABITS - THE DEVELOPMENT OF BEHAVIORAL AUTONOMY [J].

DICKINSON, A .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1985, 308 (1135) :67-78

[7] Neural systems of reinforcement for drug addiction: from actions to habits to compulsion [J].

Everitt, BJ ;

Robbins, TW .

NATURE NEUROSCIENCE, 2005, 8 (11) :1481-1489

[8] Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice [J].

Gatewood, JD ;

Wills, A ;

Shetty, S ;

Xu, J ;

Arnold, AP ;

Burgoyne, PS ;

Rissman, EF .

JOURNAL OF NEUROSCIENCE, 2006, 26 (08) :2335-2342

[9]

HITCHCOTT PK, 2007, CEREB CORTEX 0224, DOI DOI 10.1093/CERCOR/BH7010

[10]

LOVELLBADGE R, 1990, DEVELOPMENT, V109, P635

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