High molecular weight oat β-glucan enhances lipid-lowering effects of phytosterols. A randomised controlled trial

被引:36
作者
Ferguson, Jessica J. A. [1 ]
Stojanovski, Elizabeth [2 ]
MacDonald-Wicks, Lesley [3 ]
Garg, Manohar L. [1 ]
机构
[1] Univ Newcastle, Sch Biomed Sci & Pharm, Nutraceut Res Program, 305C Med Sci Bldg, Callaghan, NSW 2308, Australia
[2] Univ Newcastle, Sch Math & Phys Sci, Callaghan, NSW 2308, Australia
[3] Univ Newcastle, Fac Hlth & Med, Sch Hlth Sci, Callaghan, NSW 2308, Australia
关键词
Total cholesterol; LDL cholesterol; Triglyceride; Phytosterols; beta-glucan; LDL-CHOLESTEROL; LIPOPROTEIN CHOLESTEROL; PLANT STEROLS; METAANALYSIS; METABOLISM; GLUCOSE; BRAN; VISCOSITY; BEVERAGES; PRODUCTS;
D O I
10.1016/j.clnu.2019.02.007
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Background & aims: Oat beta-glucan (OBG) and phytosterols (PS) are known to lower blood cholesterol levels via different mechanisms. Combination of high molecular weight (MW) OBG and PS in a single functional food could have complementary and/or synergistic effects for optimising heart health. The aim of this study was to investigate the effects of dietary supplementation with high-MW OBG with or without PS on plasma lipids in hypercholesterolaemic individuals. Methods: In a double-blinded, placebo-controlled, 2 x 2 factorial trial, participants were randomised to receive biscuits fortified with either no PS or OBG (PL, n = 18) or 2 g PS (PS, n = 18). 3 g OBG (OBG, n = 18), or combination of 2 g PS and 3 g OBG (PS-OBG, n = 18) per day for 6 weeks. Primary outcome was fasting plasma total cholesterol (TC) and secondary outcomes were LDL-cholesterol, LDL-C; HDL-cholesterol, HDL-C; triglycerides, TG and TC to HDL-cholesterol (TC:HDL) ratio. Results: TC and LDL-C were significantly lowered following PS (-4.6% and -7.6% respectively; p < 0.05), OBG (-5.7% and -8.6%; p < 0.01) and PS-OBG (-11.5% and -13.9%: p < 0.0001) administration. The reduction in TC in the PS-OBG group was significantly greater compared to PL (p < 0.001) and PS (p < 0.05). PS-OBG group had a significantly greater reduction in LDL-C compared to PL (p < 0.01) but not in comparison to PS or OBG groups. TC:HDL ratio was significantly reduced following PS-OBG (-8.9%: p < 0.01) only, and there was no significant difference found between groups. Plasma TG reduced by 8.4% following PS-OBG, however, this was statistically non-significant. Plasma HDL-C remained unchanged across all groups. Conclusions: Dietary supplementation with high-MW OBG and PS in a single functional food enhances their lipid-lowering potential. Blood cholesterol lowering by PS and OBG is additive. Delivery of these two bioactive nutrients in a single food allows optimisation of their lipid-lowering effects and may provide added heart health benefits with enhanced compliance. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码:80 / 89
页数:10
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