Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

被引：4245

作者：

Nimmerjahn, A

Kirchhoff, F

Helmchen, F

机构：

[1] Max Planck Inst Med Res, Zellphysiol Abt, D-69120 Heidelberg, Germany

[2] Max Planck Inst Expt Med, Abt Neurogenet, D-37075 Gottingen, Germany

来源：

SCIENCE | 2005年 / 308卷 / 5726期

关键词：

D O I：

10.1126/science.1110647

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions. Furthermore, blood-brain barrier disruption provoked immediate and focal activation of microglia, switching their behavior from patroling to shielding of the injured site. Microglia thus are busy and vigilant housekeepers in the adult brain.

引用

收藏

页码：1314 / 1318

页数：5

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