The effects of aging on spinal neurochemistry in the rat

被引：83

作者：

Ko, ML ^{[1
]}

King, MA ^{[1
]}

Gordon, TL ^{[1
]}

Crisp, T ^{[1
]}

机构：

[1] NE OHIO UNIV,COLL MED,DEPT NEUROBIOL,ROOTSTOWN,OH 44272

来源：

BRAIN RESEARCH BULLETIN | 1997年 / 42卷 / 02期

关键词：

spinal cord; high-performance liquid chromatography (HPLC); antinociception; serotonin (5-HT); norepinephrine (NE);

D O I：

10.1016/S0361-9230(96)00216-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to investigate how the aging process alters the basal levels of serotonin, norepinephrine, dopamine, and their respective metabolites in the spinal cord using high-performance liquid chromatography and electrochemical detection, Young, mature and aged male Fischer 344 rats (5-6, 15-16, and 25-26 months old, respectively) were used in all experiments. Dorsal and ventral halves of the cervical, thoracic, lumbar and sacral vertebral sections of the rat spinal cord were analyzed, The results indicate that as chronological age increases, local spinal levels of serotonin and norepinephrine decrease, These findings are discussed in terms of how age-related changes in the endogenous levels of the biogenic amines may alter the perception of pain in the elderly. Copyright (C) 1997 Elsevier Science Inc.

引用

页码：95 / 98

页数：4

共 29 条

[1] STIMULATION-PRODUCED DESCENDING INHIBITION FROM THE PERIAQUEDUCTAL GRAY AND NUCLEUS RAPHE MAGNUS IN THE RAT - MEDIATION BY SPINAL MONOAMINES BUT NOT OPIOIDS [J].