Conversion of chylomicrons into remnants

被引:12
作者
Hultin, M [1 ]
Olivecrona, T [1 ]
机构
[1] Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden
关键词
chylomicrons; postprandial lipoproteins; atherosclerosis;
D O I
10.1016/S0021-9150(98)00229-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The turnover of chylomicrons in the blood is the sum of several processes. The native chylomicron is synthezised in the intestine out of available substrates. When the chylomicron enters the circulation exchanges of apolipoproteins with other lipoproteins, it also binds to the vascular endothelium where the chylomicron is lipolyzed by lipoprotein lipase. After a short period in the circulation the chylomicron/chylomicron remnant appears to be available for receptor mediated uptake. In this paper several of the processes involved in generation and clearance of chylomicron remnants are discussed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:S25 / S29
页数:5
相关论文
共 25 条
[1]   LIPOPROTEIN-LIPASE ENHANCES THE BINDING OF CHYLOMICRONS TO LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].
BEISIEGEL, U ;
WEBER, W ;
BENGTSSONOLIVECRONA, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8342-8346
[2]   LIVER UPTAKE OF CHYLOMICRON REMNANTS WITH HIGH AND LOW APOPROTEIN E-C RATIOS [J].
BORENSZTAJN, J ;
KOTLAR, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (18) :5863-5866
[3]  
BORENSZTAJN J, 1987, LIPOPROTEIN LIPASE
[4]  
Brunzell JD, 1995, METABOLIC MOL BASES, P1913
[5]   DEPLETION OF LIPOPROTEIN-LIPASE AFTER HEPARIN ADMINISTRATION [J].
CHEVREUIL, O ;
HULTIN, M ;
OSTERGAARD, P ;
OLIVECRONA, T .
ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (10) :1391-1396
[6]   Heparin-decasaccharides impair the catabolism of chylomicrons [J].
Chevreuil, O ;
Hultin, M ;
Ostergaard, P ;
Olivecrona, T .
BIOCHEMICAL JOURNAL, 1996, 320 :437-444
[7]   BIPHASIC EFFECTS OF LOW-MOLECULAR-WEIGHT AND CONVENTIONAL HEPARINS ON CHYLOMICRON CLEARANCE IN RATS [J].
CHEVREUIL, O ;
HULTIN, M ;
OSTERGAARD, P ;
OLIVECRONA, T .
ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (10) :1397-1403
[8]   LIPOPROTEIN-LIPASE ENHANCES BINDING OF LIPOPROTEINS TO HEPARAN-SULFATE ON CELL-SURFACES AND EXTRACELLULAR-MATRIX [J].
EISENBERG, S ;
SEHAYEK, E ;
OLIVECRONA, T ;
VLODAVSKY, I .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (05) :2013-2021
[9]  
GREEN PHR, 1981, J LIPID RES, V22, P1153
[10]  
Hultin M, 1996, J LIPID RES, V37, P1022