Regression of paroxysmal atrial fibrillation associated with thiazolidinedione therapy

被引：21

作者：

Korantzopoulos, Panagiotis ^{[1
]}

Kokkoris, Stelios ^{[2
]}

Kountouris, Evaggelos ^{[1
]}

Protopsaltis, Loannis ^{[2
]}

Siogas, Konstantinos ^{[1
]}

Melidonis, Andreas ^{[2
]}

机构：

[1] G Hatzikosta Gen Hosp Ioannina, Dept Cardiol, Ioannina 45001, Greece

[2] Tzaneio Gen Hosp Piraeus, Ctr Diabet, Piraeus, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2008年 / 125卷 / 03期

关键词：

atrial fibrillation; glitazones; rosiglitazone; pleiotropic effects; atrial remodeling;

D O I：

10.1016/j.ijcard.2006.12.063

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Thiazolidinediones (TZDs) represent insulin-sensitizing agents that have several pleiotropic properties, possibly related to their favorable effects on cardiovascular remodeling. We briefly describe 2 diabetic patients who experienced a remarkable improvement in their paroxysmal atrial fibrillation (AF) after treatment with rosiglitazone. Current evidence suggests that atria] remodeling represents a prominent mechanism of AT development and perpetuation while inflammation and oxidative stress are possibly implicated in this process. It could therefore be speculated that the pleiotropic effects of TZDs favorably affect atrial remodeling reducing the arrhythmia burden, Further studies are needed in order to elucidate the merit of this pharmacological approach in AF. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E51 / E53

页数：3

共 14 条

[1]

Is atrial fibrillation an inflammatory disorder? [J].

Boos, CJ ;

Anderson, RA ;

Lip, GYH .

EUROPEAN HEART JOURNAL, 2006, 27 (02) :136-149

[2]

The preventive anti-oxidant action of thiazolidinediones: a new therapeutic prospect in diabetes and insulin resistance [J].

Da Ros, R ;

Assaloni, R ;

Ceriello, A .

DIABETIC MEDICINE, 2004, 21 (11) :1249-1252

[3]

The future of atrial fibrillation therapy [J].

Dorian, Paul .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2006, 17 :S11-S16

[4]

Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage - Role of the NADPH and xanthine oxidases [J].

Dudley, SC ;

Hoch, NE ;

McCann, LA ;

Honeycutt, C ;

Diamandopoulos, L ;

Fukai, T ;

Harrison, DG ;

Dikalov, SI ;

Langberg, J .

CIRCULATION, 2005, 112 (09) :1266-1273

[5]

Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence [J].

Ehrlich, JR ;

Hohnloser, SH ;

Nattel, S .

EUROPEAN HEART JOURNAL, 2006, 27 (05) :512-518

[6]

ELSHERIF N, 2005, PACING CLIN ELECTROP, V28, P995

[7]

Pleiotropic effects of thiazolidinediones: Taking a look beyond antidiabetic activity [J].

Giannini, S ;

Serio, M ;

Galli, A .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2004, 27 (10) :982-991

[8]

Peroxisome proliferator-activated receptor-γ ligands regulate endothelial membrane superoxide production [J].

Hwang, JN ;

Kleinhenz, DJ ;

Lassègue, B ;

Griendling, KK ;

Dikalov, S ;

Hart, CM .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2005, 288 (04) :C899-C905

[9]

Oxidative stress and diabetic cardiovascular complications [J].

Jay, D ;

Hitomi, H ;

Griendling, KK .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (02) :183-192

[10]

Errors and pitfalls in the non-invasive management of atrial fibrillation [J].

Korantzopoulos, P ;

Kolettis, TM ;

Goudevenos, JA ;

Siogas, K .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 104 (02) :125-130

← 1 2 →