Diverse biological functions of the SPARC family of proteins

被引：256

作者：

Bradshaw, Amy D. ^{[1
,2
]}

机构：

[1] Med Univ S Carolina, Gazes Cardiac Res Inst, Dept Med, Div Cardiol, Charleston, SC 29425 USA

[2] Ralph H Johnson Vet Adm, Charleston, SC USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 03期

关键词：

SPL-1; SMOC; Testican; fstl-1; Hevin; SPOCK; Review; FOLLISTATIN-LIKE PROTEIN-1; THYROGLOBULIN TYPE-1 DOMAIN; CALCIUM-BINDING PROTEIN; INTEGRIN-LINKED KINASE; NULL MICE; MATRIX-METALLOPROTEINASE; EXTRACELLULAR-MATRIX; MATRICELLULAR PROTEINS; RHEUMATOID-ARTHRITIS; MMP-2; EXPRESSION;

D O I：

10.1016/j.biocel.2011.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The SPARC family of proteins represents a diverse group of proteins that modulate cell interaction with the extracellular milieu. The eight members of the SPARC protein family are modular in nature. Each shares a follistatin-like domain and an extracellular calcium binding E-F hand motif. In addition, each family member is secreted into the extracellular space. Some of the shared activities of this family include, regulation of extracellular matrix assembly and deposition, counter-adhesion, effects on extracellular protease activity, and modulation of growth factor/cytokine signaling pathways. Recently, several SPARC family members have been implicated in human disease pathogenesis. This review discusses recent advances in the understanding of the functional roles of the SPARC family of proteins in development and disease. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：480 / 488

页数：9

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