The first steps of protein import into mitochondria

被引:12
作者
Haucke, V [1 ]
Lithgow, T [1 ]
机构
[1] LA TROBE UNIV,SCH BIOCHEM,BUNDOORA,VIC 3083,AUSTRALIA
关键词
protein targeting; protein import; mitochondria; molecular chaperones;
D O I
10.1023/A:1022451520203
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Protein import into mitochondria is initiated by the recognition and binding of precursor proteins by import components in the cytosol, on the mitochondrial surface, and in the mitochondrial outer membrane. Following their synthesis on cytoplasmic ribosomes, some precursor proteins interact with molecular chaperones in the cytosol which function in maintaining the precursor protein in an import-competent state and may also aid in the delivery of the precursor to the mitochondria. A multisubunit protein import receptor then recognises and binds precursor proteins before feeding them into the outer membrane import site. Some proteins are sorted from the import site into the outer membrane, but most precursor proteins travel through the outer membrane import site into the mitochondria, where the later steps of protein import take place.
引用
收藏
页码:11 / 17
页数:7
相关论文
共 56 条
[1]  
ALCONADA A, 1995, MOL CELL BIOL, V15, P6196
[2]   BIOGENESIS OF MITOCHONDRIA [J].
ATTARDI, G ;
SCHATZ, G .
ANNUAL REVIEW OF CELL BIOLOGY, 1988, 4 :289-333
[3]   Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria [J].
Bolliger, L ;
Junne, T ;
Schatz, G ;
Lithgow, T .
EMBO JOURNAL, 1995, 14 (24) :6318-6326
[4]   Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats [J].
Bomer, U ;
Pfanner, N ;
Dietmeier, K .
FEBS LETTERS, 1996, 382 (1-2) :153-158
[5]   HEAT-SHOCK PROTEINS AND MOLECULAR CHAPERONES - MEDIATORS OF PROTEIN CONFORMATION AND TURNOVER IN THE CELL [J].
CRAIG, EA ;
WEISSMAN, JS ;
HORWICH, AL .
CELL, 1994, 78 (03) :365-372
[6]   DNAJ-LIKE PROTEINS - MOLECULAR CHAPERONES AND SPECIFIC REGULATORS OF HSP70 [J].
CYR, DM ;
LANGER, T ;
DOUGLAS, MG .
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (04) :176-181
[7]   BINDING OF A SPECIFIC LIGAND INHIBITS IMPORT OF A PURIFIED PRECURSOR PROTEIN INTO MITOCHONDRIA [J].
EILERS, M ;
SCHATZ, G .
NATURE, 1986, 322 (6076) :228-232
[8]  
GARTNER F, 1995, J BIOL CHEM, V270, P3788
[9]   THE TPR SNAP HELIX - A NOVEL PROTEIN REPEAT MOTIF FROM MITOSIS TO TRANSCRIPTION [J].
GOEBL, M ;
YANAGIDA, M .
TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (05) :173-177
[10]   MAS37P, A NOVEL RECEPTOR SUBUNIT FOR PROTEIN IMPORT INTO MITOCHONDRIA [J].
GRATZER, S ;
LITHGOW, T ;
BAUER, RE ;
LAMPING, E ;
PALTAUF, F ;
KOHLWEIN, SD ;
HAUCKE, V ;
JUNNE, T ;
SCHATZ, G ;
HORST, M .
JOURNAL OF CELL BIOLOGY, 1995, 129 (01) :25-34