Advances in graft-versus-host disease biology and therapy

被引：670

作者：

Blazar, Bruce R. ^{[1
]}

Murphy, William J. ^{[2
,3
]}

Abedi, Mehrdad ^{[2
]}

机构：

[1] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA

[2] Univ Calif Davis, Div Hematol & Oncol, Dept Internal Med, Davis, CA USA

[3] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95817 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 06期

关键词：

REGULATORY T-CELLS; BONE-MARROW-TRANSPLANTATION; MESENCHYMAL STEM-CELLS; PROTEASOME INHIBITOR BORTEZOMIB; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYELOGENOUS LEUKEMIA; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; DENDRITIC CELLS; SUPPRESSOR-CELLS;

D O I：

10.1038/nri3212

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders, but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past decade has brought impressive advances in our understanding of the role of stimulatory and suppressive elements of the adaptive and innate immune systems from both the donor and the host in GVHD pathogenesis. New insights from basic immunology, preclinical models and clinical studies have led to novel approaches for prevention and treatment. This Review highlights the recent advances in understanding the pathophysiology of GVHD and its treatment, with a focus on manipulations of the immune system that are amenable to clinical application.

引用

页码：443 / 458

页数：16

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