The role of neisserial Opa proteins in interactions with host cells

被引：112

作者：

Dehio, C

Gray-Owen, SD

Meyer, TF

机构：

[1] Max Planck Inst Biol, Dept Infekt Biol, D-72076 Tubingen, Germany

[2] Max Planck Inst Infekt Biol, Dept Biol Mol, D-10117 Berlin, Germany

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 12期

关键词：

D O I：

10.1016/S0966-842X(98)01365-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathogenic Neisseria spp. possess a repertoire of phase-variable Opa proteins that mediate various pathogen-host cell interactions, including bacterial engulfment by epithelial cells and opsonin-independent phagocytosis by professional phagocytes. Recent studies have identified cellular targets recognized by defined Opa proteins and have begun to reveal host signalling events involved in mediating these Opa-dependent cellular processes.

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页码：489 / 495

页数：7

相关论文

共 69 条

[1] The pathogenesis of gonococcal urethritis in men: Confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae [J].

Apicella, MA ;

Ketterer, M ;

Lee, FKN ;

Zhou, DG ;

Rice, PA ;

Blake, MS .

JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (03) :636-646

[2]

APICELLA MA, 1990, PRINCIPLES PRACTICE, P1600

[3] A PREDICTED 3-DIMENSIONAL STRUCTURE FOR THE CARCINOEMBRYONIC ANTIGEN (CEA) [J].

BATES, PA ;

LUO, JC ;

STERNBERG, MJE .

FEBS LETTERS, 1992, 301 (02) :207-214

[4] Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells [J].

Beauchemin, N ;

Kunath, T ;

Robitaille, J ;

Chow, B ;

Turbide, C ;

Daniels, E ;

Veillette, A .

ONCOGENE, 1997, 14 (07) :783-790

[5] HUMAN NEUTROPHIL RESPONSE TO RECOMBINANT NEISSERIAL OPA PROTEINS [J].

BELLAND, RJ ;

CHEN, T ;

SWANSON, J ;

FISCHER, SH .

MOLECULAR MICROBIOLOGY, 1992, 6 (13) :1729-1737

[6] CARCINOEMBRYONIC ANTIGEN, A HUMAN-TUMOR MARKER, FUNCTIONS AS AN INTERCELLULAR-ADHESION MOLECULE [J].

BENCHIMOL, S ;

FUKS, A ;

JOTHY, S ;

BEAUCHEMIN, N ;

SHIROTA, K ;

STANNERS, CP .

CELL, 1989, 57 (02) :327-334

[7] THE OPACITY PROTEINS OF NEISSERIA-GONORRHOEAE STRAIN MS11 ARE ENCODED BY A FAMILY OF 11 COMPLETE GENES [J].

BHAT, KS ;

GIBBS, CP ;

BARRERA, O ;

MORRISON, SG ;

JAHNIG, F ;

STERN, A ;

KUPSCH, EM ;

MEYER, TF ;

SWANSON, J .

MOLECULAR MICROBIOLOGY, 1991, 5 (08) :1889-1901

[8] GONOCOCCAL OPACITY - LECTIN-LIKE INTERACTIONS BETWEEN OPA PROTEINS AND LIPOOLIGOSACCHARIDE [J].

BLAKE, MS ;

BLAKE, CM ;

APICELLA, MA ;

MANDRELL, RE .

INFECTION AND IMMUNITY, 1995, 63 (04) :1434-1439

[9] Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae [J].

Bos, MP ;

Grunert, F ;

Belland, RJ .

INFECTION AND IMMUNITY, 1997, 65 (06) :2353-2361

[10]

Carey DJ, 1997, BIOCHEM J, V327, P1

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