'Green' synthesis of important pharmaceutical building blocks:: enzymatic access to enantiomerically pure α-chloroalcohols

被引：69

作者：

Zhu, DM ^{[1
]}

Mukherjee, C ^{[1
]}

Hua, L ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 19期

关键词：

D O I：

10.1016/j.tetasy.2005.08.037

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Thirty one recombinant ketoreductase enzymes were screened for the reduction of six alpha-chloroketones, the precursors of pharmaceutically valuable alpha-chloroalcohols. Several highly active and enantioselective ketoreductases were found and their applications to the synthesis of both enantiomers of these alpha-chloroalcohols were demonstrated on a preparative scale. This offers a convenient, 'green' access to this type of important pharmaceutical building blocks. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：3275 / 3278

页数：4

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