Apoptosis of smooth muscle cells is not silent: Fas/FADD initiates a program of inflammatory gene expression

被引：12

作者：

Bowen-Pope, DF ^{[1
]}

Schaub, FJ ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S1050-1738(01)00083-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unlike necrosis, apoptosis is classically considered to be "silent, " (i.e., self-contained and non-inflammatory). In this review we describe the system that we developed to regulate apoptosis of smooth muscle cells (SMC) in vivo. We have used this system to demonstrate that SMC apoptosis initiated by FADD or by Fas ligation includes a specific program of expression of pro-inflammatory genes. We discuss how this conclusion can be reconciled with reports that Fas plays an anti-inflammatory role in vascular lesions.

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页码：42 / 45

页数：4

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