Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

被引：230

作者：

Sauzeau, V

Le Mellionnec, E

Bertoglio, J

Scalbert, E

Pacaud, P

Loirand, G

机构：

[1] Fac Sci, INSERM, U533, F-44322 Nantes 3, France

[2] INSERM, U461, Chatenay Malabry, France

[3] IRIS, Courbevoie, France

来源：

CIRCULATION RESEARCH | 2001年 / 88卷 / 11期

关键词：

D O I：

10.1161/hh1101.092034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this work was to investigate the coupling of human urotensin II (hU-II) to RhoA activation and regulation of RhoA-dependent functions. The use of the Rho-kinase inhibitor Y-27632 and the development of a membrane-permeant RhoA inhibitor (TAT-C3) allowed us to demonstrate that hU-II induced arterial smooth muscle contraction, actin stress fiber formation, and proliferation through the activation of the small GTPase RhoA and its downstream effector Rho-kinase.

引用

页码：1102 / 1104

页数：3

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