Allelic dosage analysis with genotyping microarrays

被引：66

作者：

Ishikawa, S

Komura, D

Tsuji, S

Nishimura, K

Yamamoto, S

Panda, B

Huang, J

Fukayama, M

Jones, KW

Aburatani, H

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Genome Sci Div, Meguro Ku, Tokyo 1538904, Japan

[2] Univ Tokyo, Fac Med, Dept Human Pathol, Bunkyo Ku, Tokyo 1138655, Japan

[3] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 1538904, Japan

[4] Univ Tokyo, Adv Sci & Technol Res Ctr, Intelligent & Cooperat Syst, Meguro Ku, Tokyo 1538904, Japan

[5] Affymetrix Inc, Santa Clara, CA 95051 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 333卷 / 04期

基金：

日本科学技术振兴机构;

关键词：

DNA microarray; SNP typing; array CGH; oligonucleotide microarray;

D O I：

10.1016/j.bbrc.2005.06.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic alternations, including dosage and allelic imbalance, constitute a major basis of neoplastic and other genetic disorders. Using oligonucleotide genotyping microarrays, here we report the development and usage of an algorithm, called genome imbalance map (GIM) algorithm, for allelic as well as total gene dosage analysis. Using the GIM algorithm, global genome imbalance status at over 100,000 loci was simultaneously analyzed with unprecedented accuracy and allelic discrimination. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1309 / 1314

页数：6

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