Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

被引：17

作者：

Houlden, H

Rizzu, P

Stevens, M

de Knijff, P

van Duijn, CM

van Swieten, JC

Heutink, P

Perez-Tur, J

Thomas, V

Baker, M

Morris, H

Rossor, M

Jannsen, JC

Petersen, RC

Dodd, P

Dark, F

Boeve, B

Dickson, D

Davies, P

Pickering-Brown, S

Mann, D

Adamson, J

Lynch, T

Payami, H

Poorkaj, P

Bird, TD

Schellenberg, GD

Chakraverty, S

Norton, J

Morris, JC

Goate, A

Hutton, M

Hardy, J

机构：

[1] Mayo Clin Jacksonville, Jacksonville, FL 32224 USA

[2] Erasmus Univ, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands

[3] Univ Hosp Dijkzigt, Dept Neurol, NL-3015 GD Rotterdam, Netherlands

[4] Vrije Univ Amsterdam, Acad Hosp, Dept Human Genet, Amsterdam, Netherlands

[5] Erasmus Univ, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[6] Inst Neurol, Dementia Res Grp, London WC2, England

[7] Inst Neurol, Neurogenet Lab, London WC2, England

[8] Mayo Clin, Dept Neurol, Rochester, MN USA

[9] Univ Queensland, Dept Biochem, Brisbane, Qld 4072, Australia

[10] Albert Einstein Sch Med, Dept Pathol, Bronx, NY 10461 USA

[11] Princess Alexandra Hosp, Dept Psychiat, Woolloongabba, Qld 4102, Australia

[12] Univ Manchester, Dept Pathol, Manchester M13 9PT, Lancs, England

[13] Univ Manchester, Div Neurosci, Manchester M13 9PT, Lancs, England

[14] Mater Misericordiae Hosp, Dublin 7, Ireland

[15] Oregon Hlth Sci Univ, Dept Med Genet, Portland, OR 97201 USA

[16] Vet Affairs Med Ctr, Seattle, WA 98108 USA

[17] Washington Univ, Dept Psychiat & Neurol, St Louis, MO 63110 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 260卷 / 03期

关键词：

apolipoprotein E; Alzheimer's disease; frontotemporal dementia with parkinsonism linked to chromosome 17; tau;

D O I：

10.1016/S0304-3940(98)00931-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 195

页数：3

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