Posttranslational modifications of self-antigens

被引：77

作者：

Doyle, HA ^{[1
]}

Mamula, MJ ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Rheumatol Sect, Dept Internal Med, New Haven, CT 06520 USA

来源：

AUTOIMMUNITY: CONCEPTS AND DIAGNOSIS AT THE CUTTING EDGE | 2005年 / 1050卷

关键词：

posttranslational modifications; autoimmunity; T cells; antibody; antigen processing; MHC class II;

D O I：

10.1196/annals.1313.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Although the immune system has developed mechanisms to distinguish "self" from "non-self," the presence of autoimmune diseases demonstrates that these mechanisms can be bypassed. The posttranslational modification of self-antigens is one way in which "new" antigens are created for which immune tolerance does not exist. We review some of the posttranslationally modified self-antigens associated with autoimmune diseases, how they arise, and how they break immune tolerance.

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页码：1 / 9

页数：9

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