Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation

被引：40

作者：

Brusko, Todd ^{[1
]}

Bluestone, Jeffrey ^{[1
]}

机构：

[1] Univ Calif San Francisco, UCSF Diabet Ctr, San Francisco, CA 94143 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Cellular therapy; Regulatory T cells; Type; 1; diabetes;

D O I：

10.1002/eji.200738108

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune regulation is a complex process that depends on the maintenance of self tolerance while retaining robust immune responses against microbes. The emergence of Treg as a central mechanism for immune regulation has generated a new paradigm where Treg-resistant memory T cells and/or "defective" Treg lead to a breakdown in tolerance resulting in immune pathology. In this perspective, we highlight the opportunities and challenges in the field of Treg therapy.

引用

页码：931 / 934

页数：4

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