Precocious atherosclerosis in rheumatoid arthritis - Role of traditional and disease-related cardiovascular risk factors

被引:37
作者
Gerli, Roberto [1 ]
Sherer, Yaniv [1 ]
Bocci, Elena Bartoloni [1 ]
Vaudo, Gaetano [1 ]
Moscatelli, Sheila [1 ]
Shoenfeld, Yehuda [1 ]
机构
[1] Univ Perugia, Dept Clin & Expt Med, Rheumatol Unit, Monteluce Policlin, I-06122 Perugia, Italy
来源
AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS | 2007年 / 1108卷
关键词
D O I
10.1196/annals.1422.038
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The risk of cardiovascular (CV) disease increases in patients with rheumatoid arthritis (RA). This is due to a number of different triggers including traditional and disease-related factors. Among established risk factors for CV disease, smoking may exert a more dangerous effect on arterial wall in RA than in the general population by a synergic effect with inflammatory processes of the disease. Although persistent inflammation and immune dysregulation of RA may contribute to favor other well-known CV risk factors, such as dyslipidemia, it is now clear that the disease itself represents an independent risk factor for CV disease by the action of RA chronic inflammatory process as well as humoral and cell-mediated immune mechanisms. There is evidence that CV risk is associated with severity and extension of the disease and it is of interest the fact that the presence of circulating anticyclic citrullinated peptide antibodies appears to be associated with stronger evidence of subclinical atherosclerosis in RA.
引用
收藏
页码:372 / 381
页数:10
相关论文
共 70 条
[1]   Effect of anti-TNFα treatment on circulating endothelial progenitor cells (EPCs) in rheumatoid arthritis [J].
Ablin, Jacob N. ;
Boguslavski, Viktoria ;
Aloush, Valerie ;
Elkayam, Ori ;
Paran, Daphna ;
Caspi, Dan ;
George, Jacob .
LIFE SCIENCES, 2006, 79 (25) :2364-2369
[2]  
Agirbasli M, 2006, CLIN EXP RHEUMATOL, V24, P580
[3]  
Asanuma Y, 1999, ARTHRITIS RHEUM, V42, P443, DOI 10.1002/1529-0131(199904)42:3<443::AID-ANR8>3.0.CO
[4]  
2-Q
[5]   Anti-rheumatic drug use and risk of hospitalization for congestive heart failure in rheumatoid arthritis [J].
Bernatsky, S ;
Hudson, M ;
Suissa, S .
RHEUMATOLOGY, 2005, 44 (05) :677-680
[6]  
Book C, 2005, J RHEUMATOL, V32, P430
[7]  
Choi HK, 2005, J RHEUMATOL, V32, P2311
[8]   Methotrexate and mortality in patients with rheumatoid arthritis:: a prospective study [J].
Choi, HK ;
Hernán, MA ;
Seeger, JD ;
Robins, JM ;
Wolfe, F .
LANCET, 2002, 359 (9313) :1173-1177
[9]   Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis [J].
Chung, Cecilia P. ;
Oeser, Annette ;
Avalos, Ingrid ;
Gebretsadik, Tebeb ;
Shintani, Ayumi ;
Raggi, Paolo ;
Sokka, Tuulikki ;
Pincus, Theodore ;
Stein, C. Michael .
ARTHRITIS RESEARCH & THERAPY, 2006, 8 (06)
[10]   Increased coronary-artery atherosclerosis in rheumatoid arthritis - Relationship to disease duration and cardiovascular risk factors [J].
Chung, CP ;
Oeser, A ;
Raggi, P ;
Gebretsadik, T ;
Shintani, AK ;
Sokka, T ;
Pincus, T ;
Avalos, I ;
Stein, CM .
ARTHRITIS AND RHEUMATISM, 2005, 52 (10) :3045-3053