Expression of mRNAs for preprotachykinin and nerve growth factor receptors in the dorsal root ganglion following peripheral inflammation

被引:23
作者
Cho, HJ
Park, EH
Bae, MA
Kim, JK
机构
[1] Department of Anatomy, School of Medicine, Kyungpook National University, Taegu, 2-101, Dongin Dong
关键词
preprotachykinin; nerve growth factor receptor; mRNA; dorsal root ganglia; peripheral inflammation; pain; in situ hybridization;
D O I
10.1016/0006-8993(96)00026-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nerve growth factor (NGF) plays a dynamic role in the control of substance P (SP) levels and synthesis in the dorsal root ganglion (DRG). In the present study, in situ hybridization was used to examine the change of preprotachykinin (PTT), trkA and p75 mRNAs levels in the DRG after the injection of complete Freund's adjuvant into the hindpaws of rats. Peripheral tissue inflammation increased PTT and p75 mRNAs levels in the DRG, while trkA mRNA levels showed no change. These findings suggest that p75, in addition to trkA, also may be important in mediating the action of NGF on the synthesis of SP in the DRG following peripheral inflammation.
引用
收藏
页码:197 / 201
页数:5
相关论文
共 24 条
[1]   INSITU HYBRIDIZATION HISTOCHEMISTRY FOR THE ANALYSIS OF GENE-EXPRESSION IN THE ENDOCRINE AND CENTRAL-NERVOUS-SYSTEM TISSUES - A 3-YEAR EXPERIENCE [J].
BLOCH, B ;
POPOVICI, T ;
LEGUELLEC, D ;
NORMAND, E ;
CHOUHAM, S ;
GUITTENY, AF ;
BOHLEN, P .
JOURNAL OF NEUROSCIENCE RESEARCH, 1986, 16 (01) :183-200
[2]   P75 AND TRK - A 2-RECEPTOR SYSTEM [J].
CHAO, MV ;
HEMPSTEAD, BL .
TRENDS IN NEUROSCIENCES, 1995, 18 (07) :321-326
[3]   P75-DEFICIENT TRIGEMINAL SENSORY NEURONS HAVE AN ALTERED RESPONSE TO NGF BUT NOT TO OTHER NEUROTROPHINS [J].
DAVIES, AM ;
LEE, KF ;
JAENISCH, R .
NEURON, 1993, 11 (04) :565-574
[4]  
DIAMOND J, 1992, J NEUROSCI, V12, P1454
[5]   INCREASED CONTENT AND TRANSPORT OF SUBSTANCE-P AND CALCITONIN GENE-RELATED PEPTIDE IN SENSORY NERVES INNERVATING INFLAMED TISSUE - EVIDENCE FOR A REGULATORY FUNCTION OF NERVE GROWTH-FACTOR INVIVO [J].
DONNERER, J ;
SCHULIGOI, R ;
STEIN, C .
NEUROSCIENCE, 1992, 49 (03) :693-698
[6]   NGF INDUCTION OF NGF RECEPTOR GENE-EXPRESSION AND CHOLINERGIC NEURONAL HYPERTROPHY WITHIN THE BASAL FOREBRAIN OF THE ADULT-RAT [J].
HIGGINS, GA ;
KOH, SY ;
CHEN, KS ;
GAGE, FH .
NEURON, 1989, 3 (02) :247-256
[7]   P140TRK MESSENGER-RNA MARKS NGF-RESPONSIVE FOREBRAIN NEURONS - EVIDENCE THAT TRK GENE-EXPRESSION IS INDUCED BY NGF [J].
HOLTZMAN, DM ;
LI, YW ;
PARADA, LF ;
KINSMAN, S ;
CHEN, CK ;
VALLETTA, JS ;
ZHOU, J ;
LONG, JB ;
MOBLEY, WC .
NEURON, 1992, 9 (03) :465-478
[8]   3 RAT PREPROTACHYKININ MESSENGER-RNAS ENCODE THE NEUROPEPTIDES SUBSTANCE-P AND NEUROKININ-A [J].
KRAUSE, JE ;
CHIRGWIN, JM ;
CARTER, MS ;
XU, ZS ;
HERSHEY, AD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (03) :881-885
[9]   TARGETED MUTATION OF THE GENE ENCODING THE LOW AFFINITY NGF RECEPTOR P75 LEADS TO DEFICITS IN THE PERIPHERAL SENSORY NERVOUS-SYSTEM [J].
LEE, KF ;
LI, E ;
HUBER, LJ ;
LANDIS, SC ;
SHARPE, AH ;
CHAO, MV ;
JAENISCH, R .
CELL, 1992, 69 (05) :737-749
[10]   DEPENDENCE ON P75 FOR INNERVATION OF SOME SYMPATHETIC TARGETS [J].
LEE, KF ;
BACHMAN, K ;
LANDIS, S ;
JAENISCH, R .
SCIENCE, 1994, 263 (5152) :1447-1449