Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid

被引：32

作者：

Pascall, JC ^{[1
]}

Brown, KD ^{[1
]}

机构：

[1] Babraham Inst, Cambridge CB2 4AT, England

来源：

FEBS LETTERS | 1998年 / 429卷 / 03期

关键词：

Rhomboid; epidermal growth factor receptor signalling; protein processing; Spitz; Drosophila melanogaster;

D O I：

10.1016/S0014-5793(98)00622-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Drosophila regulatory protein Rhomboid has been demonstrated genetically to facilitate signalling within the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. Using a polymerase chain reaction (PCR)based strategy, we have cloned a human cDNA which encodes a protein that has high sequence similarity to Rhomboid, The encoded protein, termed rhomboid-related protein (RRP), is predicted to contain seven transmembrane domains. Northern analysis indicates that RRP mRNA is expressed at highest levels in brain and kidney. (C) 1998 Federation of European Biochemical Societies.

引用

页码：337 / 340

页数：4

共 14 条

[1] RHOMBOID, A GENE REQUIRED FOR DORSOVENTRAL AXIS ESTABLISHMENT AND PERIPHERAL NERVOUS-SYSTEM DEVELOPMENT IN DROSOPHILA-MELANOGASTER [J].