Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis

被引：57

作者：

Schwarz, EM

Looney, RJ

O'Keefe, RJ

机构：

[1] Univ Rochester, Med Ctr, Dept Med, Immunol Rheumatol, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Dept Orthopaed, Rochester, NY 14642 USA

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 03期

关键词：

aseptic loosening; osteolysis; pannus; prosthesis; tumor necrosis factor-alpha;

D O I：

10.1186/ar81

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aseptic loosening of total joint arthroplastics due to periprosthetic osteolysis is a frequent cause of implant failure. The absence of clinical interventions to arrest or prevent this complication limits the use of total joint replacement especially in younger patients. Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening.

引用

页码：165 / 168

页数：4

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